I explained poor grades in my PS. Let's say that you can explain away any poor grades in person if you make it to an interview. Well, you still need to make it to your interview and all they have to go on before that point is your GPA, MCAT, and personal statement. It's really your only chance to put something in the application, other than your numbers, that they will definitely read.
I had called Temple specifically because I was concerned about a few poor grades, Temple Admissions told me that if I was concerned about it at all, that I should touch on it in my personal statement.
Now, I wasn't super specific about any of it. I didn't say for instance, "this one professor was a prick and nobody liked him and he didn't cover the material that was in the test" because that's kinda just making an excuse. I approached it more from the angle of "there was a period of time where I wasn't sure what I wanted to do and I didn't see how these classes were aplicable and I didn't give it my all, but now I'm different, as evident in my recent upward trend because blah blah blah". I basically just wanted them to be aware that I'm aware that poor grades are inexcusable and that for whatever reason it won't happen again.
That being said, there are probably lots of people that don't touch on that kind of stuff in their personal statement and get plenty of interviews and acceptances. I just used the PS as my opportunity to lay everything on the table from my perspective, in a way that they couldn't see from looking at my GPA or MCAT or other experiences.
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