- Joined
- Jan 13, 2009
- Messages
- 535
- Reaction score
- 7
Hi all, I'm a bit confused about this disease. So I understand it's a result of a mutation of JAK2 which causes constitutional de-activation and removes the need for EPO stimulation. Rubin's Pathology says that this de-coupling of stimulus/response occurs at the GFU-E stage of erythrocyte development(which, from what I understand is past the point of no return for differentiating into a specific cell type). So my confusion comes in understanding why with Polycythemia Vera patients have high platelets and neutrophils. If someone could enlighten me or direct me towards a source, I'd greatly appreciate it. Thanks!