SDN Members don't see this ad. (About Ads) Are there any disadvantages to majoring in Kinesiology versus my current Physiology major? My Physiology major seems to require a lot more difficult courses such as calculus based physics, advanced organic chemistry, etc... Some of the classes I have no interest in taking. The ones I do not want to take also seem to be some of the harder ones, so that is why I am considering changing my major. Does it really matter what you major in as long as you take all of the prerequisites?