I would advise a balanced schedule for both the Fall and the Spring. From my own experience, in the Fall of senior year, I took Biochem I, Physics I+lab, Intro to Psych, a research class + lab = easy schedule. In the Spring of senior year, I took Epidemiology of Infectious Dz, Microbial metabolism, Lab simulation of Physiology, Physics II + lab, Human Anatomy + lab = difficult.
So let me explain my reasoning, I planned the Fall semester of senior year to be easy to go to interviews and then take all the hard courses in the Spring to compensate in order to graduate on time and still get good grades
What I didn't realize was that I got more post-December interviews (which is during Spring semester of senior year) than I got pre-December (Fall semester) interviews. Thankfully my choice school invited me for one of the pre-December interviews so I got a chance to decline post-December interviews to focus on grades and graduation. But I do think it's important to consider these factors because it could potentially affect your grades and ultimately the academic update if your choice school invites you post-December.
Hope this helps. ^^