What second messangers do I need to know???

[Coastalbarley]

World had an asterisk at the end of an review portion and said its important to know them all, but it only talked about cAMP

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[Coastalbarley]

i take boards on tuesday so the help is appreciated

 

[RySerr21]

i take boards on tuesday so the help is appreciated

do you have the kaplan biochem book? Its got a pretty good review of second messengers and signaling cascades....it made a pretty big deal of this as well...

Pathways to know....


cAMP

PIP2/IP3/DAG

cGMP

Insulin, growth factors

 

[Fuzuli]

cAMP vs. PLC-IP3
As a rule of thumb, hypothalamic > cAMP; hypophyseal > IP3

• CRH/ACTH is cAMP; GHRH is IP3
• FSH/LH/hCG is cAMP; GnRH and oxytocin is IP3
• TSH is cAMP; TRH is IP3
• ADH (V2) is cAMP; ADH (V1) is IP3
• Beta-1 and -2 receptors are cAMP; alpha-1 is IP3; alpha-2 is Gi

Some important hormones using cAMP

• PTH and calcitonin: Their effects are reverse, but they use the same second messenger system
• Glucagon: Maybe the most important one.

cGMP: Vasodilators

• ANP
• EDRF
• NO: Directly stimulates cGMP synthesis

Tyrosine kinase: Growth hormones

• Insulin and IGF-1
• EGF: Herceptin (transtuzumab) binds to these receptors
• FGF/VEGF: Avastin (bevacizumab) binds to VEGF receptors

Steroid hormones
Based it on adrenal cortex. These receptors are located inside cytoplasm.

• Zona glomerulosa: Aldosterone
• Zona fasciculata: Glucocorticoids
• Zona reticularis: Sex hormones (estrogen, progesterone, testosterone)
• Vitamin D

Non-steroid hydrophobic hormones
Similar to steroid hormones

• Thyroid hormones: So for thyroid gland: TRH is IP3, TSH is cAMP and thyroid hormones have intranuclear receptors.
• Vitamin A

 

[IMnotgivingup!!]

ya i would definitely know the second messengers. I had 1-2 questions on it and one of my friends had even more than that. So know them well and then those will be easy points.

 

[Coastalbarley]

do you have the kaplan biochem book? Its got a pretty good review of second messengers and signaling cascades....it made a pretty big deal of this as well...

Pathways to know....


cAMP

PIP2/IP3/DAG

cGMP

Insulin, growth factors

where at in the book, i have it but never read it

 

[RySerr21]

where at in the book, i have it but never read it

haha seriously dude? Open it up and look at the table of contents or search in the index. C'mon, i cant study for you too.

 

[Coastalbarley]

haha seriously dude? Open it up and look at the table of contents or search in the index. C'mon, i cant study for you too.

ahh fair enough, thanks for the heads up though

 

[dozitgetchahi]

This is a streamlined review sheet of receptors/2nd messengers I downloaded from here a while back. It looks pretty comprehensive.

 

[Coastalbarley]

cAMP vs. PLC-IP3
As a rule of thumb, hypothalamic > cAMP; hypophyseal > IP3

• CRH/ACTH is cAMP; GHRH is IP3
• FSH/LH/hCG is cAMP; GnRH and oxytocin is IP3
• TSH is cAMP; TRH is IP3
• ADH (V2) is cAMP; ADH (V1) is IP3
• Beta-1 and -2 receptors are cAMP; alpha-1 is IP3; alpha-2 is Gi

Some important hormones using cAMP

• PTH and calcitonin: Their effects are reverse, but they use the same second messenger system
• Glucagon: Maybe the most important one.

cGMP: Vasodilators

• ANP
• EDRF
• NO: Directly stimulates cGMP synthesis

Tyrosine kinase: Growth hormones

• Insulin and IGF-1
• EGF: Herceptin (transtuzumab) binds to these receptors
• FGF/VEGF: Avastin (bevacizumab) binds to VEGF receptors

Steroid hormones
Based it on adrenal cortex. These receptors are located inside cytoplasm.

• Zona glomerulosa: Aldosterone
• Zona fasciculata: Glucocorticoids
• Zona reticularis: Sex hormones (estrogen, progesterone, testosterone)
• Vitamin D

Non-steroid hydrophobic hormones
Similar to steroid hormones

• Thyroid hormones: So for thyroid gland: TRH is IP3, TSH is cAMP and thyroid hormones have intranuclear receptors.
• Vitamin A

I got a question right because of how easy you grouped this, thanks

 

[WashMe]

Dude I love SDN so much... people post the best study aids, advice, etc. It would have taken me a long time to put this information together on my own.

 

[shigella123]

cAMP vs. PLC-IP3
As a rule of thumb, hypothalamic > cAMP; hypophyseal > IP3

• CRH/ACTH is cAMP; GHRH is IP3
• FSH/LH/hCG is cAMP; GnRH and oxytocin is IP3
• TSH is cAMP; TRH is IP3
• ADH (V2) is cAMP; ADH (V1) is IP3
• Beta-1 and -2 receptors are cAMP; alpha-1 is IP3; alpha-2 is Gi

Some important hormones using cAMP

• PTH and calcitonin: Their effects are reverse, but they use the same second messenger system
• Glucagon: Maybe the most important one.

cGMP: Vasodilators

• ANP
• EDRF
• NO: Directly stimulates cGMP synthesis

Tyrosine kinase: Growth hormones

• Insulin and IGF-1
• EGF: Herceptin (transtuzumab) binds to these receptors
• FGF/VEGF: Avastin (bevacizumab) binds to VEGF receptors

Steroid hormones
Based it on adrenal cortex. These receptors are located inside cytoplasm.

• Zona glomerulosa: Aldosterone
• Zona fasciculata: Glucocorticoids
• Zona reticularis: Sex hormones (estrogen, progesterone, testosterone)
• Vitamin D

Non-steroid hydrophobic hormones
Similar to steroid hormones

• Thyroid hormones: So for thyroid gland: TRH is IP3, TSH is cAMP and thyroid hormones have intranuclear receptors.
• Vitamin A

this is so helpful!

 

[ChessMaster3000]

this is so helpful!

According to FA, GHRH is cAMP

 

[shigella123]

According to FA, GHRH is cAMP

Yeah, I'm going with first aid 2014 after finding that out. I got NBME question wrong about signalling pathways cuz I couldn't remember which one belongs to which group so I was searching for better way to remember and found this post, but not so helpful. So, I will be coming up wtih my own way to remember it.

Do you have a better way to remember them?

 

[ChessMaster3000]

Yeah, I'm going with first aid 2014 after finding that out. I got NBME question wrong about signalling pathways cuz I couldn't remember which one belongs to which group so I was searching for better way to remember and found this post, but not so helpful. So, I will be coming up wtih my own way to remember it.

Do you have a better way to remember them?

actually, I thought this was a good mnemonic, and i think that was the only error.

i just go with FLAT ChAMP and goat hag per first aid

 

[Myxedema]

According to FA, GHRH is cAMP

Costanzo LS, Physiology, 5th Ed., Chapter 9, p. 390: "Phospholipase C Mechanism (IP3, Ca2+) ... GHRH". Op. cit., p. 399: "...In initiating its action on the somatotroph, GHRH binds to a membrane receptor, which is coupled through a G s protein to both adenylyl cyclase and phospholipase C. Thus, GHRH stimulates growth hormone secretion by utilizing both cAMP and IP 3 /Ca 2+ as second messengers."
The same table is also in BRS Physiology, Chapter 7, p. 224.

 

[ChessMaster3000]

Costanzo LS, Physiology, 5th Ed., Chapter 9, p. 390: "Phospholipase C Mechanism (IP3, Ca2+) ... GHRH". Op. cit., p. 399: "...In initiating its action on the somatotroph, GHRH binds to a membrane receptor, which is coupled through a G s protein to both adenylyl cyclase and phospholipase C. Thus, GHRH stimulates growth hormone secretion by utilizing both cAMP and IP 3 /Ca 2+ as second messengers."
The same table is also in BRS Physiology, Chapter 7, p. 224.

myxedema you have outdone yourself. So, would you argue that they wouldn't directly ask which mechanism GHRH uses since it's both?

 

[Myxedema]

myxedema you have outdone yourself. So, would you argue that they wouldn't directly ask which mechanism GHRH uses since it's both?

Yes, they probably won't.