I disagree that you do not get any meaningful results until you solve the structure. I've worked in an x-ray crystallography lab for two years now and can say that although the "big picture" isnt complete until the structure is solved, you can publish good papers based on the biochemistry of your protein. In fact, that's what most non-structure and structure based labs do. Pick up JBC and Biochemistry and you'll see my point. I do not personally know a single crystallography lab that focuses solely on structure determination. They focus on solving structures as well as the biochemistry or cell biology of their protein/s. You can either use this information to supplement your structure paper or publish it on its own. For example, you can look at allosteric regulation of the protein. The process of getting suitable crystals is a paper all in its own. You also learn a great deal about the proteins solubility based on the crystal screens, which help you develop new protocols for protein purification. Acta crystallographica loves this sort of thing. And, if you think this journal is not very good, just look at its impact factor. This sort of research is exactly what I've done. I have a first author paper based on the protein purification and crystal preparation of my protein. I'm currently writing another paper based on the biochemistry of my protein before I knew its structure. And, I have a joint first author paper based on its structure and cell biology, which is in a top-notch journal. So, results are based on you, not the technique of crystallography. Protein structure determination is a technique that is very powerful and can gain you a lot of recognition. It is difficult, but what isn't. It seems to me that people are very vision oriented. We can look at a large object and decipher how it works because we can visually see how it works. As items get smaller, we can only do 'blind' experiments to determine how it works. Crystallography helps 'regain your sight' of how proteins and DNA interact. This is a very poweful tool. So, I'll shut up and give a big