Yes to some of the above, and bosh folklore for others. Just as surgical gloves are somewhat porous, and double gloving helps increase protection from virus, so, too, does a minor amount of transudation through the plastic bag occur, but not so much as to alter what is provided. Incidentally, there is usually a ~/>5% surplus over nominal volume for priming lines, etc. (By the way, when you infuse the entire replace bag including its overfill, do you "count" that overfill volume, or simply assume it? In overload prone, or dialysis dependent patients, large uncounted volumes might confuse the issue.
The manufacturer's instructions or website are the best source upon what to expect. Small amounts of damp within the protective over-wrapper for shipping (which should not be removed in advance of need) may be ignored provided there is no true leak in the bag.
Other plastics, such as the polyolefin bottles, do not have the same degree of permeability.
In routine use, not pressurized lines, an air-fluid meniscus is important to determine volume infused without a pump-controller.
The extra bag space is also useful for admixture of additives (NaHCO3, Vitamins, Drugs, etc.) by the pharmacy, but the true volume should be calculated for concentration or Intake and Output measurements.
Sincerely,
Jacksonrees