I know lots of folks doing this from SF and LA. There are a lot of jobs at either Napa, Coalinga, and Atascadero state hospitals. Starting pay is about $240K and they work 4 days a week, 10 hours a day. A couple of the folks I know doing this drive out on their "Monday" for 2-4 hours (depending on where they live), rent a cheap apartment in these places and stay three nights, and drive home after their last shift, leaving three days and four nights at home.
Alternately, there are a lot of contract jobs at places like Stockton (as well as the state hospitals mentioned above) that pay very high hourly rates and you can stack the hours and work 3-4 days/week. They provide housing while you are there (but no benefits).
Also, you don't need to go to the boonies for such jobs. There are jobs within easy commute of LA/SF (one hour or less) that you can work 3-4 days/week and make a nice salary. I commute 40 minutes to a PES that pays about $2400/shift.
Keep in mind, the situations, salaries, and opportunities I'm describing above are VERY different from one locale to the next.