Zietman Editorial

[RadOncDoc21]

Did you know that Lebron is no better at basketball than I am? This one time I challenged him to a free throw contest. He only sunk 9/10 and I sunk 8/10. The HR is 1.2, so there you have it, I'm not inferior.

I'm sure the refs cheated like they always do for Lebron, so he might even be more inferior than you!

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[napoleondynamite]

Touche. The possibility of Type II error exists for any comparison. In your example glancing at the CI for the HR would make it clear that your inference is weak. Let's hypothesize that the HR in the hypothetical trial is 0.91. Confidence interval is 0.75-1.08. Is this sufficient to accept non-inferiority?

I admit it..you are smarter than I am! You totally lost me.

But all I'm saying is I look at these noninferiority studies with a skeptical eye and with prostate cancer or breast cancer expect follow-up for longer than 6 years to reach meaningful conclusions.