Mais's quick comp. to CP errors

SLUsagar said:

As the book, although a great 1st-aid 4-the boards type resource, has some reported errors so i've been told, can someone send out a list of errors (at least major ones) they've come across for the mais quick compendium to CP book, especially for us newbie CP's reading it for the first time while starting CP? Might be helpful for everyone.

thanks
🙂

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Not to worry. I talked to Mais a few months ago, and he's aware of the errors and is planning on releasing a second edition, with pictures, hopefully by the end of the year.

Adrian Cocot said:

Not to worry. I talked to Mais a few months ago, and he's aware of the errors and is planning on releasing a second edition, with pictures, hopefully by the end of the year.

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Yup. This was confirmed to me by someone on the ASCP book committee.

Tell Mais to PLEASE hurry up so those of us studying for 2008 boards can get it in time!!!🙂

Damn, I just got my mais in the mail today 🙁

P 3.34, under AML with recurrent cytogenetic abnormalities:

AML with inv(16)(p13q22) or t(16;16)(p13;q22) -- "these structural abnormalities result in the apposition of the MYH11 (myosin) and CBF-beta genes", as opposed to CBF-alpha as printed which is actually implicated in AML with t(8;21)(q22;q22), as it is coded for by AML1.

I love this book... I will happily spring for a new edition when it comes out.

SLUsagar said:

As the book, although a great 1st-aid 4-the boards type resource, has some reported errors so i've been told, can someone send out a list of errors (at least major ones) they've come across for the mais quick compendium to CP book, especially for us newbie CP's reading it for the first time while starting CP? Might be helpful for everyone.

thanks
🙂

Click to expand...

1.22 - Picture - Beta region has two bands in CSF, not aalpha 2 region, and what is currently in the betta region in both lanes should be in the gamma region.

1.23 - As previously noted, move the second alpha 1 band and every band below it down one in all lanes.

1.31 - 5.3.2 - Trisomy 21 should have DECREASED AFP and ELEVATED B-HCG

3.7 Chart. Although these are correct, be careful because the anode and cathode traditionally flipped between the basic and the acid gel, and the basic gel is usually run first.

3.21 Most common cytogenetic abnormality in CLL is del of 13q, not trisomy 12.

3.31 CMML with eosinophilia, the abnormality is normally on ch 12 (not 5)

4.8 - Table and text on EBV antibodies. Text says EBV-Ea is positive first, then heterophile antibodies, the table implies the opposite (see early acute line), Jones seems to be in line with the table.

4.15 - Table - first line pictures are of trophozoites, second line is of cysts

Thats all I remember from breifly reskimming the book.

Just one example in favor of the compendium, the description of the Hugh-Leifson OF medium is correct while the description in the Osler Notes is wrong.

error on page 1.7 (2005 edition):

slope of L-B plot is Km/Vmax and competitive inhibition will increase slope compared to plot of uninhibited enzyme (Km increases and Vmax stays same).

Since the inhibitor and substrate compete for the same site, raising the substrate concentration can eventually overcome the inhibitor, and Vmax can be achieved. Although Vmax can be reached, a competitive inhibitor raises Km, indicating that the affinity of the enzyme for the substrate is lower in the presence of the inhibitor. The effect of a competitive inhibitor in a Lineweaver-Burk plot is both to move the x-intercept and increase the slope.

🙂

sohsie said:

1.31 - 5.3.2 - Trisomy 21 should have DECREASED AFP and ELEVATED B-HCG

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Along these lines -- trisomy 21 should also have decreased unconjugated estriol, whereas Mais states incorrectly that it is increased.

Also, for the neural tube defect pattern, Mais says the uE is decreased, but it can also be normal.