Interesting case...Diff Dx?

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mailee88

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We have a patient on our inpatient service who came in yesterday afternoon...very interesting so far...wanted to see what you guys think this is...

HPI: (as reported by his father) 20 year old WM, previously healthy, was at work when he fell down some stage steps. The patient's co-workers did not see the fall but state that he started acting strangely approximately 30 minutes after the fall, was clenching his hands and reaching for things but falling short of grabbing them. The patient also complained of dizziness and nausea. MAST ambulance was called. Upon arrival, the patient was combative and unresponsive to verbal commands. Pt was then sedated and had to be intubated in the ED in order to get CT.

The parents report him being a normal, healthy 20 year old with no previous episodes like this. They also state that he was very normal the night before, had dinner together, and watched a movie at home.

PMH: none
Medications: none
FH: non-contributory
SOCIAL HISTORY: No drugs, no alcohol, no tobacco. Electrician. Lives with his parents.

GENERAL: A 20-year-old white male with no obvious signs of trauma who is intubated, and on vent.
VITAL SIGNS: Tmax 102.1, Tc 99.2 Blood pressure 104/38, pulse 60, respirations 10, saturating 100% on 40% oxygen.
HEENT: Normocephalic atraumatic. The patient's pupils are equal, round and reactive to light and accommodation, although sluggish. No obvious signs of trauma.
CHEST: Lungs clear to auscultation bilaterally.
CARDIOVASCULAR: S1 and S2, no murmurs.
ABDOMEN: Soft with a large scar in his abdomen from surgery as a child. No masses are noted. Bowel sounds are positive.
EXTREMITIES: No edema, 2+ pulses, decreased reflexes bilaterally in lower extremities.
NEUROLOGIC: The patient is intubated. Pupils are equal, round and reactive to light and accommodation. No Babinski is noted. The patient is moving all extremities.

LABORATORY/PERTINENT DATA: CT and MRI of the head are negative
INR 1.29. CBC: White blood cell count 16.5, H&H 14.2 and 41 with platelets of 197. BMP showed a sodium of 140, potassium 3.6, chloride 101, CO2 of 25, BUN of 10 and creatinine 0.8. Blood glucose 121.

UA and UDS were both negative

Currently, the patient is still intubated and sedated with propofol. Trial in decreasing propofol was done today in which the patient failed and became combative. The patient is currently on prophylactic phenytoin. ???????????
 
Is there any history of childhood trauma, abuse, etc., or family history of psychiatric disorders (often an IM family history doesn't include asking specifically about these things, that's why I ask). Given his age and gender, it could be the first presentation of schizophrenia. Yaaay haldol! 😉

Also, I want to know more about this childhood surgery! Do you have any details? And is there a diff on that white count? It seems a bit high, although I don't know what your lab's normal ranges are.
 
Hi

Absolutely with MustafaMond. Get an LP, now that you have a normal CT scan. He has an elevated WBC and was febrile, presented with a nonfocal exam and mental status changes.

At this point I'd try to r/o meningitis, drugs, withdrawal from something. Then obviously the zebras...

lf
 
100%-->must have LP. As posted by the others, altered mental status, white count, negative CT...must proceed with LP.
 
Definately an LP, but also must consider VB dissection, insufficiency due to trauma so get an MR angiogram, also must consider complex partial SZ with his behavior so get EEG. Interesting case. You should always think VB TIA, dissection when you see nausea, vomiting, dizziness, ataxia. His symptoms fall into a select few of Wallenberg's syndrome, although not completely. Let us know.
 
Update:
Still combative and unresponsive to commands with attempts to extubate. Tmax today of 100.8, no differentiate on CBC. We are thinking encephalitis, menigitis, etc. Doing LP today...will keep you updated. Oh, and no childhood history of anything.
 
What is his surgery from? Did he have a splenectomy? Be careful of encapsulated organs -> sepsis. His story doesn't truly fit a sepsis picture, as he was 100% fine the night before, he's holding his pressure and isn't tachycardic, but it is something to think about.

LP without delay.

Unsure of his source of fevers.

Did you do a tox screen on him?

Q, DO
 
After the LP, I'd also get an EEG to r/o status (and the tox screen). Also, does the guy take dietary supplements/herbals/etc? Had a 23 year old come in with word salad secondary to ephedra.
 
I had the day off, but have an update on the case from a colleague. Tried again to wean off propofol. Patient was awake for about 12 mins, opened eyes, responded to name, and indicated by nodding his head that he wanted the tube out of his throat. Will try to exubate tomorrow or later today.

LP bacterial serology is negative. Completed clean, no WBCs, normal protein/glucose. Still awaiting viral serology.

Resp Culture showed
MANY POLYMORPHONUCLEAR LEUKOCYTES
MANY GRAM POSITIVE COCCI SUGGESTIVE OF PNEUMOCOCCI
MANY GRAM POSITIVE COCCI IN CLUSTERS
Awaiting final results. These are prelim.

Blood culture negative (final)

Repeated UDS...negative yet again 🙂

Vitals: Tmax 102.3, Tcurrent 101.7 HR 117, Resp 22, BP 114/45
WBC decreased to 12.3, with left shift (19 bands)

Talking about getting an EEG. Will probably await final results of CSF before taking this next step. Thanks for your input everyone. Still a very interesting case...will be sure to keep everyone updated on this young man's progress.
 
By the way, we didn't do a complete tox screen just yet. I will suggest this to the team tomorrow. We got an alcohol level and have been watching his dilantin (which we put him on proph.) EtOH is negative.

No over the counter medications/herbs/supplements report by family
 
CXR showed hilar infiltrates. Final resp culture grew up 2+ S.aureus. The pt. is now on Zosyn and Vanc for nosocomial vs. aspiration pneumonia. Planning on doing an EEG, since this is likely some kind of seizure disorder, and not encephalitis. Still awaiting CSF viral serology. Pt is still spiking fevers and has a white count of 8.5, with a left shift. Tried to extubate yesterday without success (desat'ed to 85%). Now on 50% FiO2 and sat'ing 98-99%.
 
As promised...here's the latest...still the weirdest case I have, and everyone else in this hospital has ever seen...

Last Friday, he was extubated...finally. Been very slow to speak and slow with moments lately. Now that his pneumonia is mostly resolved with IV antibiotics, he is no longer running fevers. He has also been taken off of Propofol and put on Haldol. After talking with him after he was extubated, he doesn't complain of anything. All ROS were negative. He says that he remembers tripping and falling off the stage and hitting his head. He then remembers getting in the elevator with his co workers, and that's the last memory he has of the whole event. Didn't feel sick or anything the day of or the day before.

After a tough weekend, today, he is being very strange...seeing hallucinations (dead people), also very restless, keeps repeating movements. He would sit on the bed for a bit, then get up, sit in the chair for a minute and then up again and walk over to the comode and sit on that for a minute. Then he would do crossword puzzles for about a minute, and then lay back in bed. He would repeat this same sequence over and over, all day and all night long. After asking him about why he is doing this, he could only tell me that it's not his mind telling him to, but his body and that his body can't stop moving. He also states he feels very jitterly and that his body has to keep moving. He still is not complaining of anything. It seems that his mind is pretty clear. He can tell me that he feels like he is very slow with his thinking, and that he isn't as sharp as before. He feels like everything he does is slow. On exam of him, he walks very slowly, a shuffling gait, and all his movements are slow. He also seems very distant, can't focus on one thing for more than a minute. Very alert and knows where he is at and passed his mini mental status exam. Everything seems okay...but he is acting very strangely. We are taking him off of all sedatives and checking an EEG today...hopefully will get some answers...Any thoughts at all?? ICU PSYCHOSIS???
 
Any travel hx?
How about swimming ponds
Any arthralgias
Rash?

I think you guy has bought us all a ticket to the zoo, so with that said, I would add serology for:

autoimmune antibodies - thinking maybe Still's disease

how about titers for leptospirosis?

Just throwing in my two cents, realizing that you only get a penny for your though, who makes that other oenny?
 
Interesting case! How about a ceruloplasmin and a fundoscopic exam to r/o another zebra - Wilson's. I didn't see mention of abn. LFT's.
 
Hmm...didn't think about all that...basically today he is doing a lot better. He is able to communicate more clearly and doesn't seem so jitterly and restless anymore. Parents and friends say that he is pretty much back to his baseline. Question that it may be haldol W/D causing some of his psych symptoms..but not likely...we took him off all meds today (haldol, ativan,etc) and sent him up to the floors...will see how he is tomorrow...perhaps we may never know ;(
 
I'm wondering if those impulsive movements you described might be a form of akathisia, which can result from haldol administration. Haldol might also explain the motor slowing you described, given its D2 blocking ability.

I'm still wondering if he has a family history of schizophrenia.
 
We did diagnose him with akathsia from haldol...which has been improving. he is doing well today, almost back to how he was. so we are discharging him...no h/o schizo in family...we were thinking that too...right age, etc...but his thinking/mental status doesn't suggest schizo...he's more aware of his surroundings..and his ability to communication is good too...who knows?? 🙂
 
Interesting case, indeed.... Consider posting a thread with this one linked in the Neurology forum. They might be able to help out, too.
 
hmm interesting case. Has anyone considered Syphillis? I think Schizophrenia should be high on the list as some previous posts have suggested. would be great to learn how the pt turns out.
 
I'm most interested in getting the results of the viral culture (though not even that is 100% sensitive). Still sounds like a viral encephalitis of some kind to me.
 
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