I'm certainly hoping it's possible to get in with no experience!
I seriously think you should bring up your non-pharmacy retail experience, especially if it was cashiering. I work in a Kroger as a cashier, and I'm willing to bet there are a whole lot of parallels.
For example, if you cashier, you're already used to getting yelled at over the dumbest things. If you can hold that job down for any more than a few months, chances are you can effectively deal with those types of situations. I don't know how it is elsewhere, but my manager likes to pick on me to make phone calls (mainly when the self-scanners are broken, I get to call the company and explain problems and sometimes set up repair times), which parallels to calling insurance companies and doctors (especially all the time spend on hold, I'm sure pharm calls are just as bad.) Also, any sort of interpersonal communications issues are the same... like getting those people that just want to talk and talk when you've got a line to go away, or telling hicks that hit on you and stare at your chest "no thanks" without offending them so much that they never come back to the store (does that happen in a pharmacy, or do interns tend to get more respect? The Kroger polo shirts aren't low cut enough that people can see down them, so stop leaning over the belt and trying to look!!!!!!! I'm a cashier, not a stripper! Um... sorry. Cashier angst.)
...at least, that's how I'm going to put in in my interview when they ask me how I know I want to work as a pharmacist when I don't have any pharmacy experience. That, and my boyfriend is in pharm school at the moment (2nd year), so I read his notes and I know very well what I'm getting myself in to.
It seems to me that as long as you have a well-prepared and believable reason that you want to get into pharmacy, not having work experience shouldn't be a terrible barrier.