Graft-versus-host can be of benefit to???

E

ENThopeful

Full Member

10+ Year Member

Joined

Oct 3, 2008

Messages

278

Reaction score

1

Points

4,551

• Jun 7, 2009

• #2

i THINK gvh type reaction is used in treatment for some cancers, i remember faintly from class. anyone who knows more feel free to elaborate

 

Upvote 0 Downvote

I

igottaquestion

Full Member

10+ Year Member

15+ Year Member

Joined

Jun 16, 2008

Messages

268

Reaction score

6

Points

4,531

1. Medical Student

• Jun 7, 2009

• #3

My memory is only faint also. I want to say it's (at least some of) the leukemias. Having a small # of CD8+ cells from the graft can help kill cancer cells. I also want to say that they don't fully kill the bone marrow in the host before the transplant, as that's supposed to help. The details of which cancers and how to treat them with GVH are probably Step 2 stuff at best.

 

Upvote 0 Downvote

stickshift

Automatics are for noobs

10+ Year Member

Joined

May 31, 2009

Messages

62

Reaction score

2

Points

4,551

Location

With a clutch pedal

1. Medical Student

• Jun 7, 2009

• #4

Aye, the graft vs. host effect is beneficial for the leukemias/lymphomas because the donor T cells help fight the malignant blood cells remaining in the recipient. So in this case, it's more appropriately termed "graft vs. leukemia" effect.

 

Upvote 0 Downvote

Depakote

Pediatric Anesthesiologist

Moderator Emeritus

Lifetime Donor

Verified Member

Physician

Rocket Scientist

15+ Year Member

Platinum Member

Joined

Nov 2, 2004

Messages

20,793

Reaction score

111

Points

4,691

Location

SOCMOB

1. Attending Physician

• Jun 7, 2009

• #5

stickshift said:

Aye, the graft vs. host effect is beneficial for the leukemias/lymphomas because the donor T cells help fight the malignant blood cells remaining in the recipient. So in this case, it's more appropriately termed "graft vs. leukemia" effect.

Click to expand...

👍

 

Upvote 0 Downvote

swimmy

Junior Member

10+ Year Member

7+ Year Member

15+ Year Member

Joined

Dec 29, 2005

Messages

19

Reaction score

0

Points

0

Location

NY

1. Medical Student

• Jun 16, 2009

• #6

Here's the research. http://content.nejm.org/cgi/content/extract/350/6/614

 

Upvote 0 Downvote

RisingSun

Member

15+ Year Member

20+ Year Member

Joined

Jul 16, 2003

Messages

629

Reaction score

3

Points

4,696

Location

Transcontinental

1. Resident [Any Field]

• Jun 16, 2009

• #7

stickshift said:

Aye, the graft vs. host effect is beneficial for the leukemias/lymphomas because the donor T cells help fight the malignant blood cells remaining in the recipient. So in this case, it's more appropriately termed "graft vs. leukemia" effect.

Click to expand...

I wonder if the same applies for autoimmune diseases - like of someone with RA or SLE sees improvement after transplant.

 

Upvote 0 Downvote

psychforme

Mighty horse shoe

15+ Year Member

Joined

Feb 23, 2008

Messages

1,475

Reaction score

10

Points

4,701

• Jun 16, 2009

• #8

I wish people would warn before they post things ripped from the nbmes

 

Upvote 0 Downvote

I

Ihateverbal

Full Member

10+ Year Member

15+ Year Member

Joined

Oct 13, 2006

Messages

492

Reaction score

1

Points

4,531

• Jun 17, 2009

• #9

Ugh I reasoned through that question and got it right

But for some reason, I still did pretty poorly on NBME 5 and dropped from my previous NBME =(

I hope it was a fluke.

 

Upvote 0 Downvote

neil100

anti-dummies

10+ Year Member

15+ Year Member

Joined

Jan 8, 2008

Messages

1,367

Reaction score

0

Points

0

• Jun 17, 2009

• #10

stickshift said:

Aye, the graft vs. host effect is beneficial for the leukemias/lymphomas because the donor T cells help fight the malignant blood cells remaining in the recipient. So in this case, it's more appropriately termed "graft vs. leukemia" effect.

Click to expand...

👍 Tip.

Simply put. I also thought of the same thing.

Plus, the lungs would not be heavily involved in graft-versus-host since it doesn't have significant population of the immune cells or lymphoid tissue. I mean there are type II penumocytes but that's really about it.


For BM, and ileum (peyer's patches) it makes much more sense.

 

Upvote 0 Downvote