crystalloid vs colloid fabricated studies!

anesguy said:

This link was sent to me by one of my attendings. Pretty sad if it's true.

http://www.medpagetoday.com/Anesthesiology/Anesthesiology/25198

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Orin said:

Yeah, I saw that in the news too. The March issue of A&A has an article trying to figure out what's true in the aftermath.

http://www.anesthesia-analgesia.org/content/112/3/507.full

That's is just an unbelievable case of fraudulent research.

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proman said:

What's even worse is that he apparently didn't fabricate data. That's bad enough. His real data shows that colloids may actually be harmful. That would be significantly worse.

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fakin' the funk said:

What's his motive? $$$ from the HES manufacturers? I know there was recently quite a lot of excitement about the tetrastarches.

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Irregularities in Boldt's research were first noticed last year by readers of the U.S.-based journal Anesthesia and Analgesia, which had published a Boldt study of interleukin-6 levels associated with colloidal albumin and HES solutions.

According to the journal's editor, Steven L. Shafer, MD, three readers contacted the journal to say that the standard deviations in the paper's reported IL-6 concentrations seemed too small to be believable.

Shafer, describing the events in an editorial in the journal, said he checked with experts on IL-6 biology who agreed that the standard deviations were not plausible. He indicated that a close reading disclosed other suspicious findings.

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For example, although half the patients in the study supposedly received albumin-based priming solutions, no albumin solutions had been used or bought by the hospital in nearly 10 years.

Additionally, there were no records to support the paper's assertions of having received IRB approval or patients' written consent, and Boldt admitted to board investigators that he had forged co-authors' signatures on the manuscript submission.

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Idiopathic said:

I had almost completely abandoned synthetic colloid in my practice prior to this, i think ill watch from the sidelines.

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