1,2 and 1,4 addition

[wbloo]

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Hey can someone please explain to me what 1,2 and 1,4 additions are in organic - for some reason I forgot how to do them. - Thanks!

 

[pasionatdentist]

Lucky you that I was just reading it....

1. (1,2 addition)= happens when the temp is low (-40) and it is under kinetic control.

2. (1,4 addition) = happens in high temp and under thermodynamic control

 

[wbloo]

thanks, but one more question,

with what reagents do you use for 1,2 or 1,4 additions?

 

[tranv117]

theyre addition reactions so go through a carbocation. so i believe it should be polar protic solvents

 

[GCT]

Hey can someone please explain to me what 1,2 and 1,4 additions are in organic - for some reason I forgot how to do them. - Thanks!

Research kinetically favored versus thermodynamically favored.