Step I 17-hydroxylase deficiency

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Tajima

Tajima

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10+ Year Member
Why are LH levels elevated in females with 17-hydroxylase deficiency? UW ID 6753
 
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LH normally serves to cause an increase in estrogen. Without 17-a-hydroxylase, you can't produce androstenedione, and without androstenedione, you can't make estrogen way down the line, so there's no negative feedback to lower the production of LH.
 
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