Just took the COMLEX yesterday, and pretty much everything that I people have told me about it has been right.
There was a large emphasis on neuro. I didn't get any straight medial lemnicus lesions, but I did get two brain stem lesions . I had every type of cranial hematoma imaginable. There were 4 or 5 herniated disc questions (download Goljan's HY notes). I also had a smattering of behavioral disorders, some asking for treatments with CNS drugs. There was a lot of CNS pharm on my test--15 q's or so--including all of the antidepressants, seizure drugs, local anesthetics, but no inhaled anesthetics. I was asked a "what type of drug did this person use" for the recreational drugs. There were some questions on sleep that I wasn't expecting. I did have some path on cerebral edema, aneurysms, strokes that were actually quite hard to answer. There were a few cerebral artery q's with a CT. Only one optic loss q, no CNS embryo, no thalamus/hypothalamus, nothing on the ear, only one question about upper cortex function--nothing on wernicke/broca/hemineglect/dyscalculia, nothing on pupil reflexes or nystagmus. There were a few questions on nociceptive innervation of abdominal organs. Overall, HY Neuroanatomy was pretty useful (it is needed to answer those brain stem infarct q's!), though there was definitely some q's that weren't in there.
I was disappointed to only have one brachial plexus question--and you couldn't answer it if you only looked at FA (though an astute person might be able to narrow it down)--knowing just the branches is not enough. The best resource that I ran across for the brachial plexus was the COMLEX Review book by Shah/Modi.
After neuro, there was a ton of micro w/ micro pharm. I had two helminth q's, the first one being a second order question about the nature of the worm given the history. Know all of the big bugs (Strep, Staph, STDs, Neisseria, Klebsiella, Tb, Mycoplasma, Pseudomonas etc.)--there weren't many questions at all about obscure bugs, and I certainly didn't see anything that wasn't in FA. I did get a question about zoonotic bugs. There was a lot of GI symptoms on the test, but they didn't ask about many of the bugs from the diahrrea table in FA. They expected us to know a lot about Staph and Strep. There wasn't anything on ADP ribosylation and mechanism. There were several STDs. Proteus showed up a few times. Definitely know most common associations with bugs, such as aspiration pneumonia, alcoholic pneumo, adult meningitis, neonate meningitis, etc. Know treatments of all bugs!! The pharm section of micro was the second highest tested pharm section that I had. There were two fungus questions. Viruses....really wasn't much on the test. I had to diagnose a cluster of well known viral diseases. There was nothing on vaccines or classifying viruses in a family or by RNA/DNA/enveloped/etc.
There were about 10 immunology questions which was surprising. I studied immuno well, but I hadn't heard this from other people. Take this only for my own experience since others did not have any immuno. I read the immunology section out of the back of Lange's Medical Micro and Immuno. It's 80 pages or so, with a few chapters that can be safely skimmed--labs (low yield) and hypersensitivities (gone over it a billion times). This resource was EXCELLENT and prepared me well for answering online q-banks as well as for the COMLEX. The questions revolved mostly around interleukin functions, hypersensitivity associations, and immune deficiencies. In FA, be able to associate what type of immune deficiency with the presenting symptoms. There weren't any q's on CD's, MHC disease associations (except for B27, ha!), mechanism of T/B/macrophage activation, or lymph node architecture.
The OMM on my test was another large chunk, maybe 20-25 questions. Three quarters of those were viscerosomatic correlations. They were mostly straightforward, but be sure to be able to differentiate between heart, lungs, esophagus and then between stomach, liver, gallbladder, pancreas, spleen. It isn't enough to know foregut T5-9 since many times there was more than one choice in that range and you needed to know more specifically which levels. As far as review books, I don't like either Savarese (not enough detailed information, but good explanations and practice tests) or Shah/Modi (the first edition has a bagillion errors and I personally don't like the format, but you can use it to review some relevant anatomy, especially brachial plexus) as a single source. I definitely had a few questions on the lower extremity that I was a bit clueless on--and I am knowledgeable in OMM. I would get a different resource for ankle mechanics since the review books were not enough for what I had. I had one sacrum question, 3 q's on segment diagnosis, and a few random integrated anatomy and OMM questions--I wish they had more of these because that is really how OMM is practiced: the patient has a dysfunction, based on this dysfunction and your knowledge of anatomy which of the following is true. I also had one or two definition questions.
There wasn't that much pharm outside of micro and CNS; if you had a comprehensive pharm final at your school, you're pretty much set--just be sure you know what's in FA. The questions were few, and when they were there were straightforward questions about either mechanism or well-known side affect. Though, I did get a question on a GI drug that wasn't in FA. I guess I would recommend going through a pharm review book before knowing FA.
There was a lot of pathophysiology in cardiology. I had 4 EKGs, no heart sounds, but many preload/afterload, pulmonary HTN questions. As far as the rest of the systems, there wasn't a lot of phys or pathophys in a direct question, though many times my knowledge helped me rule out wrong answers. There were no renal or respiratory phys calculations.
There wasn't a lot of pathology on my test. The majority of questions were about straight diagnosis. There was also a smattering of disease morphology, but not too much. There was a lot of endocrine and reproductive path, as well as reproductive subjects in general (fetal/placental anatomy, OBC phys, endometrial endocrine, lactation, gestational diseases). There were also a good handful of hematology questions, von Willebrand's, DIC, serum sickness, Rho(D) positive, hemophilia. I didn't get any q's on lymphoma, leukemia, onco-genes, tumor suppressor genes, tumor markers, carcinogens. There was a question on blastic bone metastasis, hemochromatosis, sickle cell anemia, howell-jolly bodies, antiphospholipid ab syndrome, factor V leiden mutation, Coombs test. There were many questions dealing with hypo/hyperthyroidism (one even integrated with reproductive phys), processes and mechanisms of DM, SIADH, diabetes insipidus.
There were no embryology questions.
There were only a few behavioral/ethical questions, and they were strange. One asked me about the requirements for medicaid to kick in on a nursing home patient after her medicare runs out, and another asked me about hospital reimbursements.
There were maybe ten biochemistry questions, mostly on general metabolism of starvation states, and a few on random metabolism questions. No advice on what to study for them, because I didn't study much of biochem. There were no questions on vitamins, nothing on molecular biology.
There wasn't as much anatomy as I thought there would be. I think there were more biochem q's than straight anatomy questions. HY Gross plus online qbanks are more than enough.
Overall, this test was much easier than I thought it was going to be. I had doing USMLEWorld for the past couple of weeks. The emphasis is much closer to a generalized family practice test, with many diagnoses and not as many second or third order questions. Those questions are there, just not as many as the USMLE. There are also sets of questions towards the end of the blocks that have 2 to 4 questions per vignette, that are either easy (basically a second order split up into two different questions--what is the diagnosis, what is the treatment) or more challenging than the USMLE type questions, in my opinion. I actually think that the COMLEX is more suitable to a medical practice, whereas the USMLE is geared towards medical researchers. The kinds of questions that require you to 'assume' something is exactly the kind of situation that is represented in the clinic. Getting a good score seems easier on the USMLE since FA and the online qbanks cover the unique points that are tested, the rest of the battle just consists of the mental gymnastics--which is doable for anyone that has gotten this far.
Therefore, go through tables of 'most common' associations in a patient population, disease presentation, and disease type, such as the table in the back of FA.
Top subjects that were represented on my test in this order:
neuro
neuro pharm
micro
micro pharm
OMM
cardiology
reproduction
endocrinology
Sources that are good to read:
BRS Phys (the entire thing, including the neuro chapter, especially cardiomyocyte phys)
HY Neuro + class notes for peripheral nervous system
HY Gross
Micro Ridiculously Simple (perfect for this test, you won't see the nit-picky questions like you do on the qbanks)
BRS Path (perfect for boards, RR Path is better to use during the year); don't memorize, skim; use UW to learn path
Savarese OMM Review + another text for LE (the questions in the back of Savarese are spot on, for the most part)
Lange Microbiology and Immunology (use it for the immunology, perfect depth and breadth)
USMLEWorld instead of Kaplan COMLEX or USMLE (the explanations are excellent, I learned more from this than using FA)
Update: I scored a 660, 93. Finished about 50% of USMLEWorld, and was getting low 70's on random sets of 50 at the end. Had 3.5 weeks to prepare. Wish I had finished 100% of UW and read more biochem.