2012 First Aid errata confusion: Pyrazinamide

[littlejuan]

This is listed in the corrections from www.firstaidteam.com

Page: 212

Entry title: Pyrazinamide

Correction: Pyrazinamide works by blocking pyrazanamide, not mycobacterial fatty acid synthase I.



What exactly do they mean by the bolded. I'm a bit confused.

---

Members don't see this ad.

 

[DoctwoB]

This is listed in the corrections from www.firstaidteam.com

Page: 212

Entry title: Pyrazinamide

Correction: Pyrazinamide works by blocking pyrazanamide, not mycobacterial fatty acid synthase I.


What exactly do they mean by the bolded. I'm a bit confused.

I think the errata needs an errata. According to wiki
Pyrazinoic acid was thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids[7] although this has been discounted.[8] It was also suggested that the accumulation of pyrazinoic acid disrupts membrane potential and interferes with energy production, necessary for survival of M. tuberculosis at an acidic site of infection. Further studies reproduced the results of FAS I inhibition as the putative mechanism first in whole cell assay of replicating M. tuberculosis bacilli which have shown that pyrazinoic acid and its ester inhibit the synthesis of fatty acids.[9] This study was followed by in vitro assay of tuberculous FAS I enzyme that tested the activity with pyrazinamide, pyrazinoic acid and several classes of pyrazinamide analogs. Pyrazinamide and its analogs inhibited the activity of purified FAS I.[10] Pyrazinoic acid binds to the ribosomal protein S1 (RpsA) and inhibits trans-translation. This may explain the ability of the drug to kill dormant mycobacteria.[11]

I'd say that there is contraversy about it so it probably won't be asked, but if pressed then say it inhibits FASI