AAMC 11 nomenclature question?

[MMa23]

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This was on the ebola biology passage, in the chart it has CatB (-/-),CatB (+/+), CatL (-/-) and CatL (+/+). I have only taken the intro bio classes and I am not quite familiar with this nomenclature (?)

It says next to the chart that this is the culture cell genotype. So does this mean that a CatB -/- means two recessive genes so does not have CatB? Alternatively would a (+/-) be a heterozygote and still express CatB?

 

[Sports Junky]

This was on the ebola biology passage, in the chart it has CatB (-/-),CatB (+/+), CatL (-/-) and CatL (+/+). I have only taken the intro bio classes and I am not quite familiar with this nomenclature (?)

It says next to the chart that this is the culture cell genotype. So does this mean that a CatB -/- means two recessive genes so does not have CatB? Alternatively would a (+/-) be a heterozygote and still express CatB?

Yes, you are essentially correct on all your assumptions.

The (+) usually indicates a wild-type genotype, and the (-) indicates a mutation.

The phenotype is determined by the specific gene in question. For example, one trait may be incomplete without both wild type alleles, and another gene may function normally even with one wild-type allele present.

In most cases though, one wild-type allele is usually sufficient to mask the deficiencies of the mutated allele.

 

[dontbeanegaton]

Yeah, in that question -/- is the double knockout. They add CatL and CatB one at a time and at the same time to those knockouts.