AAMC FL1 BB #23

[663697]

The passage states that p65 and cRel are transcription factors that can be continuously activated when mutations occur to proteins upstream in the signalling pathway. I had chosen B at first but changed it because I thought that transcription factors bind to DNA-binding sites on enhancer sequences, not promoters. From the information I have found online, some sources state that they can bind to either one. So, do these end up having different functions?

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[Nugester]

You know these transcription factors are continuously activated and are upstream from your genes of interest. What is upstream from these genes? Usually enhancers, silencers, promoters etc. I don't think it is important to focus that transcription factors must bind here and there, because they can bind to all that I mentioned. If you look at A, C, and D those are way weaker/wrong when compared to B. It's important to trust your instincts; if you have some correct knowledge, go with it!