Step I abetalipoproteinemia and CNS

[Africa]

Advertisement - Members don't see this ad

can u please explain how abetalipo causes CNS disease such as ataxia and retinitis pigmentosa. also what about hemolytic anemia. thanks.

 

[eur]

since your not absorbing fat, you cant absorb fat soluble vitamins (a,d,e,k). the lack of Vit E causes all those symptoms you just described. You can then treat them with Vitamin E. I think thats right.

 

[QuantumMechanic]

since your not absorbing fat, you cant absorb fat soluble vitamins (a,d,e,k). the lack of Vit E causes all those symptoms you just described. You can then treat them with Vitamin E. I think thats right.

Why are there no symptoms of A, D, or K deficiency?

 

[megaman123]

The most severe effects come from Vitamin E def - neurological demyelination and anemia. The other vitamin def do manifest such as visual problems, but they are not as severe. For our purposes, abetalipoproteinemia manifests almost exactly like vitamin E def. also, vitamin E def manifests similar to B12 def but without the megaloblastic changes in the anemia.