About Th1 and Th2 interaction witch each other,please help

[ketap]

hi,i want to ask about the T helper interactions with each other..if Th1 INF blocks the Th 2 and Th2 IL10 blocks the Th1 ...so, is it true that if we have an intracellular pathogen infection, we won't have any Antibodies produced and we will not have CMI but only Antibodies in extracellular pathogen infection? if there are also Antibodies and CMI produced in those two diseases..where are they coming from?

best regards,Ketap

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[notbobtrustme]

It's not that simple unfortunately.

Everything in biology is concentration dependent. At the site of infection, where you want activated macrophages and CMI, you will have predominantly IFN-g and IL-12 secretion to drive CMI. However, every pathogen gets ingested by macrophages and transported to lymph nodes, where TH2 cytokines are secreted (eg IL-10) preferentially.