Achondroplasia & Frontal Bossing?

Started by alamo4
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alamo4

alamo4

Dudeist
10+ Year Member
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Anyone know what the mechanism is for the frontal bossing in achrondroplasia?

Having done some searching around, I just see it listed as a feature of the condition, not any real mechanism listed. I could imagine that is a response to hematopoetic demands from smaller than normal long bones (and consequently small amounts of marrow), but presumably achrondroplasia reduces the total blood volume a bit as well. It could be something to do with a feedback response for some some other endocrine/growth signaling, or something mixed.

Thoughts?
 
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