activation of trna

[cage92]

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hey from where arise the amino acid during activation of t-rna? please if can anyone explain bcz i didnt understand this concept

 

[swamifez]

Most of the amino acids come from other cells in your body, but 9 of them, your cells can't generate, so they get it from food you eat. The the tRNA transfers activated aminos acids to the ribosomes to be used in the assembly of the proteins. Remember there are 20 types of t-RNA, each withich combines specifically with one of the 20 amino acids and carries that amino acid to the ribosomes, where it is incoporated with the protein molecules. Hopes this clarifies things.

 

[aspiringmd1015]

aminoacyl trna synthetase adds the amino acid to the trna according to the codon on the mrna and anticodon on the trna(which determines which AA it will bind), this process called "charging" also requires ATP.

 

[cage92]

thanks guys so as translation give us amino acid we require amino acid (t rna activation) to make protein so the amino acid source for charging is from external ressource?

 

[aspiringmd1015]

translation gives you a chain of amino acids(peptide chain) and the AA has to come externally from the diet if its essential(meaning we have no mechanism of manufacturing the essential AA in our body) otherwise we make them on our own, and within the cell those AA can be from either source.

 

[cage92]

thans for the explanation i have another question fa mention that if incorrect bond is hydrolysed than he mention that a mischarged t rna reads usual codon but insert wrong amino acid? how is that since if amino acid is wrong he will hydrolyse the bond

 

[aspiringmd1015]

idk what youre saying but i know the enzyme aminoacyl trna synethatase has self checking functions to make sure the right amino acid is added on its corresponding trna, but however if that self checking function misfucntions, then the inorrect amino acid will be added (trna with anticodon will still base pair with the codon of the mrna, but it will bring it the wrong amino acid)