Addiction neuroscience books

[Symmetry11]

Can anyone recommend addiction neuroscience books to a beginner?


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[splik]

my two favorite papers on the biological basis of addiction (they are a bit technical):
Everitt BJ, Robbins TW. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Rev Neurosci 2005; 8:1481-1489
Kalivas PW, Volkow ND. The neural basis of addiction: a pathology of motivation and choice. Am J Psychiatry 2005; 162:1403-1413

If you want a more accessible book - The Biology of Desire: Why Addiction Is Not a Disease by Marc Lewis - he is a neuroscientist who was a drug addict himself. It's obviously a little biased because he uses the science to support his own argument that addiction isn't a disease but a habit, but it's no more biased that the literature that claims addiction is a disease. Some would argue he is just splitting hairs and the distinction between learning and disease models is a false one, but I have to say I agree with him that there are quite significant implications that make it inescapable not to address.

 

[HarryMTieboutMD]

The problem with starting with papers is that this is a a very complex and controversial topic (no different than anything else in psychiatry- or medicine for that matter), and a Nora Volkow review from 2005 might be completely contradicted by a Nora Volkow review from 2010. A lot of the original work was done in murine models and Pet scans, and different fMRI techniques seem to constantly build on the reward/motivation story. Now with optogenetics and the ability to target specific cell populations, what was speculative can now be confirmed (at least in rodent models) Karl Diesseroth's lab just recently published a paper in Science demonstrating the mPFC exerting top down control over the striatum, which was strongly suggested but never proved.

Anyway, for a beginner I like the chapter on addiction from Stahl's Psychopharmacology, though realizing the limitations that it is overly simplistic, speculative, and poorly referenced. However, it's a place to start, and then you can search for reviews from Nora Volkow, George Koob, Mark Gold, Eric Nestler, etc

 

[downwithDTB]

Now with optogenetics and the ability to target specific cell populations, what was speculative can now be confirmed (at least in rodent models) Karl Diesseroth's lab just recently published a paper in Science demonstrating the mPFC exerting top down control over the striatum, which was strongly suggested but never proved.

Citation? I can't find anything recent in science... You mean nature?

 

[OldPsychDoc]

There was a very nice recent review by Volkow & Koob in NEJM-- 374: 363-371 January 28, 2016

 

[HarryMTieboutMD]

Citation? I can't find anything recent in science... You mean nature?

http://www.ncbi.nlm.nih.gov/pubmed/26722001