Addisons and Hypercalcemia

[Ihateverbal]

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Anyone know why addisons would cause hypercalcemia? This is one of the things that cause hypercalcemia says first Aid in the endocrine section.

 

[Depakote]

Anyone know why addisons would cause hypercalcemia? This is one of the things that cause hypercalcemia says first Aid in the endocrine section.

Harrison's says it's mild to moderate hypercalcemia due to "unclear reasons"

edit: in 10-20% of patients

 

[quietude]

Harrison's says it's mild to moderate hypercalcemia due to "unclear reasons"

edit: in 10-20% of patients

Until I saw this, I was going to suggest it was because cortisol causes hypocalcemia (and thus osteoporosis) by decreasing Ca intestinal absorption. So lack of cortisol --> increase in Ca intestinal absorption --> possible swing to hypercalcemia.

But Harrison says unclear, I'll go with unclear.

 

[neil100]

Until I saw this, I was going to suggest it was because cortisol causes hypocalcemia (and thus osteoporosis) by decreasing Ca intestinal absorption. So lack of cortisol --> increase in Ca intestinal absorption --> possible swing to hypercalcemia.

But Harrison says unclear, I'll go with unclear.

Yup my thought process was similar to yours. It's kind of odd that it would cause hypercalcemia. Harrison's is probably correct.

Kind of like thalasemmia but in that you don't have really high iron levels. It's usually normal. Unless you foolishly give iron and induce fenton rxn.