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what's the difference? Best I can tell Pick is strictly limited to frontal and temporal lobe involvement whereas Alzheimers can involve the whole cortex(but preferentially the frontal, temporal, and parietal lobes). The only histopath difference is that the intracellular tau in AD is hyperphosporylated and called "NF tangles" while the intracellular aggregated tau in Picks disease are called Pick bodies. In terms of symptoms you get dementia with both obviously, and things like disinhibition/parkinsonian symptoms, and aphasia which are associated with Pick's also come about in AD(except only sometimes PD symptoms).....
so what(except for the frontotemporal only involvement in picks) are the meaningful/testable differences between these two?
so what(except for the frontotemporal only involvement in picks) are the meaningful/testable differences between these two?