Amoxicilline - once a day

[Bonny2007]

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Has anybody heard about unlicensed administration of Amoxicilline 250mg only once a day for 15 days?

 

[WVUPharm2007]

Might be post coital UTI prophylaxis. Or a person with poor ass renal function. Or an error.

 

[Requiem]

What do you mean by unlicensed?

But, amoxicillin should never be dosed as that. You need to have a constant serum level above the MIC for B-Lactams to be effective; time-dependent kill.

If pt. was almost anuric, I think it'd be more along the lines of 50-100 mg q8h, you lower the dose, never extend the interval. For B-lactams anyway.

The post-coital thing is interesting, might be right. Should be TMP/SMX though.

 

[WVUPharm2007]

If their kidneys are shot, you can give 'em 250-500mg q24....I've seen it before...and I've seen it work before. I'm talking CrCls of under 15....

I dunno, see what globalrph says. That website knows everything. It's like the ****ing oracle or some ****.

 

[Aznfarmerboi]

or it the other patient is taking another renal holding drug like probencid. . . etc

 

[sdn1977]

Yeah - I've seen this. Its not unlicensed, but "off label" & normally dosed for post-coital use.

Normally, all it takes is one & perhaps two doses.

Yeah - it really works, altho septra is the usual drug of choice. But, if you have a pt with a sulfa allergy - this will work ust fine.

 

[Bonny2007]

I called the doctor, just to be on the safe side. Prophylaxis, pt with catheter. Doc insisted on the dose.