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Been scratching my head over this one -
Had a question on a popular qbank that was discussing the causes of anasarca. The question stem basically described a man with anasarca, marked HTN, and UA with trace protein and a bunch of RBCs. The answer for the cause of his peripheral edema was acute glomerulonephritis.
The explanation given was somewhat circular in reasoning - third spacing--> decreased volume sensed by the kidney-->activation of RAS-->peripheral constriction & inc capillary hydrostatic pressure-->third spacing
But my question is - what causes the third spacing to begin with?? I understand this process completely if you apply this to nephrotic syndrome - but for this, I'm puzzled.
Any thoughts/clarification would be greatly appreciated.
Had a question on a popular qbank that was discussing the causes of anasarca. The question stem basically described a man with anasarca, marked HTN, and UA with trace protein and a bunch of RBCs. The answer for the cause of his peripheral edema was acute glomerulonephritis.
The explanation given was somewhat circular in reasoning - third spacing--> decreased volume sensed by the kidney-->activation of RAS-->peripheral constriction & inc capillary hydrostatic pressure-->third spacing
But my question is - what causes the third spacing to begin with?? I understand this process completely if you apply this to nephrotic syndrome - but for this, I'm puzzled.
Any thoughts/clarification would be greatly appreciated.