Can you provide examples. I get what you mean, but when I'm making my cards, I think the cards I made are pretty clear, but when someone else reads it that may not be the case.
It's more about whether you'll find the card clear in a few months when you forget them.
Personally, I like my cards to be clearer than usual probably because I type all of my answers...meaning that if I block out chunks of words I will probably get the card wrong. I think my memory is fuzzier when I don't have to type out the word correctly. I also usually try not to have more than 2 cards made per Note unless it's a really dense set of info.
The first one is probably fine, it's just kind of annoying to have a cloze that wants 'Giardia' when you literally have the word 'giardiasis' showing, and vice-versa. Those feel kinda wasted because you're not even making yourself remember anything, really.
The second one is again fine, it gets you to explore "Giardia Class ⇄ diplomonads" "Diplomonads feature ⇄ 2 equal nuclei" and "Giardia feature ⇄ 2 equal nuclei". Again, I tend not to like a ton of context cues, though, so I would probably lump "diplomonads=2 equal nuclei" and just remember "Giardia ⇄ diplomonads = 2 equal nuclei"
{{c1::Giardia}} are classified as {{c2:: diplomonads}} because they have {{c2::two equal nuclei:: defining characteristic}}.
Also note that this example is fine for Giardia, but if you were doing, say, Trypanosoma and you cared about knowing multiple kinetoplastids, your first Cloze would not have a specific answer.
The third one is I think the one that actually bugged me.
{{c1::Fecal-oral transmission}} are when microorganisms transmitted in water grow in the {{c2::intestines}} and leave the body in {{c2::feces}}. Resulting in {{c2::water pollution}}
There are only little things, but for me they add up. First, that 'are' would cause me to get the card wrong everytime because it's not grammatically consistent with the answer. I guess that's just me, though. I actually like the way you split out 'intestines' vs 'feces'. But that last bit, "Resulting in water pollution" is a sentence fragment with no clear answer. There's no reason why feces automatically results in water pollution, so the relationship you're remembering isn't really accurate. It just feels like something pulled from a slide to cram memorize without actually clearly defining the Front:Back relationship you are trying to ingrain into your memory. This card would look something like "Result of fecal oral transmission" → "Water pollution" which I don't think would be a strong card. There's definitely a relationship to water pollution, but it's not the one the card makes.
I guess that's the trick for Clozing. You should make the cards knowing which relationships you are exploring. What would be on either side of this card if you were making it as a Front/Back card? If that relationship isn't clear or important, if it wouldn't make a strong Basic card, it's likely not a strong Cloze card. And, if you're getting the answer from how the card is written or other Clozes that are revealed during the question, it's not as educational. Are you remembering "Giardia ⇄ acute gastroenteritis", which is your real goal, or just that "Giardia ⇄ giardiasis", which is kind of a gimme?
Overall these are pretty good cards, tbh. And I'm sure they're working for you. Again, I'm picky because I type my answers and I don't like wiggle room in my Anki cards or I'll let myself off the hook. Just don't be afraid to update these if they start making less sense to you when you are answering them 3mo down the line and they don't feel right once you've forgotten why you made them this particular way.