antibiotic question (macrolide?)

[bchurchmanpac]

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Hey pharmD friends!
I have a question regarding antibiotic classifications
I had a professor today classify CLINDAMYCIN as a MACROLIDE.....now I always place this as a lincosamide....NOT a macrolide...I realize they both affect ribosomal subunits...but I did not feel calling clindamycin a macrolide is appropriate..he said its a form of a macrolide??....its like calling an aminoglycoside a macrolide....am I way off base here?

Thanks

 

[thephoenician88]

ask him whether someone allergic to erythromycin could take clindamycin

 

[bchurchmanpac]

I am certain the risk of an allergic reaction to erythromycin in the setting of a clindamycin allergy would be very uncommon as they have very different chemical structures...and I have prescribed clinda in e-mycin allergic patients

 

[npage148]

This is why dentists do crazy things when prescribing. No, it's not a macrolide

 

[croquemonsieur]

professor is obviously confusing clindamycin with clarithromycin

 

[bchurchmanpac]

I didn't think so...well....I knew so...it was during a micro lecture...so hopefully when they formally cover pharmacology there wont be horrible errors....

 

[clerkmaxwell]

professor is obviously confusing clindamycin with clarithromycin

This.

 

[xiphoid2010]

Does clinda have a macrolide ring in its structure? Definition right there.

 

[clerkmaxwell]

Does clinda have a macrolide ring in its structure? Definition right there.

Clinda's structure is quite different.

 

[xiphoid2010]

Clinda's structure is quite different.

That's the point. If there isn't a 12+ member ring structure, its by definition not a macrolide.

 

[mustang sally]

I have had physicians express their concerns to me about patients taking clindamycin when they have an allergy to a macrolide. So it must be a common mistake that people make.

 

[zelman]

I have had physicians express their concerns to me about patients taking clindamycin when they have an allergy to a macrolide. So it must be a common mistake that people make.

Everyone knows "...mycin" means macrolide. Just like "...prazole" means proton pump inhibitor. Funny how my aripiprazole doesn't work as well as prilosec did. Must be because it's from Japan.

j/k. It's a lincosamide. There are just too few of them for people to remember it's a drug class (two if memory serves).

 

[PharMed2016]

That isn't to say that there won't be cross-resistance since they bind to a similar area on the 50S ribosomal subunit.

 

[StewardshipDude]

he is wrong, but it doesn't matter. you will write/develop protocols and order sets and make recommendations based upon what your financial masters tell you to do - and that is to use vanc, even if the MIC is 2.0.

 

[mustang sally]

Everyone knows "...mycin" means macrolide. Just like "...prazole" means proton pump inhibitor. Funny how my aripiprazole doesn't work as well as prilosec did. Must be because it's from Japan.

j/k. It's a lincosamide. There are just too few of them for people to remember it's a drug class (two if memory serves).

Lol. Never thought about confusing aripiprazole with a PPI before.

 

[npage148]

I will admit that I thought tapazole was an antifungal while in pharmacy school. 🙄

 

[owlegrad]

When I first heard nystatin, I thought it was a statin. 😳

 

[zelman]

When I first heard nystatin, I thought it was a statin. 😳

Hmmm... Maybe we could make a master list of "name doesn't match class" drugs. We could probably get the ISMP to publish it.

 

[Ackj]

When I first heard nystatin, I thought it was a statin. 😳

Had a patient call it "new york statin" as if it was written "NY statin." When she called for a refill I had no clue what she meant until I skimmed the profile and found no cholesterol meds.

 

[owlegrad]

Hmmm... Maybe we could make a master list of "name doesn't match class" drugs. We could probably get the ISMP to publish it.

I bet you are right!

 

[clerkmaxwell]

Had a patient call it "new york statin" as if it was written "NY statin." When she called for a refill I had no clue what she meant until I skimmed the profile and found no cholesterol meds.

There's actually some underlying truth to that; Nystatin being named after the New York State Health Department.