Step I antipsychotic side effects question

[johndoe3344]

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FA is being confusing... can someone let me know if I got this right?

High potency, typical: HIGH extrapyramidal, LOW anticholinergic, LOW other
Low potency, typical: LOW extrapyramidal, HIGH anticholinergic, HIGH other
Atypical: LOW extrapyramidal, LOW anticholinergic, HIGH other

Where by "other" I mean anti- alpha1, H1, serotonin side effects.

 

[kaleerkalut]

FA is being confusing... can someone let me know if I got this right?

High potency, typical: HIGH extrapyramidal, LOW anticholinergic, LOW other
Low potency, typical: LOW extrapyramidal, HIGH anticholinergic, HIGH other
Atypical: LOW extrapyramidal, LOW anticholinergic, HIGH other

Where by "other" I mean anti- alpha1, H1, serotonin side effects.

I believe this is correct. The only part I'm unsure about is the Atypical "LOW anticholinergic". Hopefully somebody else can chime in as well.

 

[MrBeauregard]

Yes, this is correct.

With the atypicals, instead of worrying about 5-HT2, alpha, dopamine or H1 effects, you need to worry about weight gain/diabetes with both Clozapine and Olanzapine. Clozapine obviously needs weekly checks for agranulocytosis. Ziprasidone can also cause QT prolongation.