I know of someone who developed pancreatitis and had to be hospitalized.
My philosophy is this: if I get a needle stick from a high risk patient, I'll take the prophylaxis. If the side effects bother me, I can always stop. However, if I delay starting prophylaxis, I can't just start it anytime. I would rather start it and have the option to stop it than not have the option to start it because I waited too long.