One of my good friends had his sights set on Mayo coming into the application cycle. It was one of his top choices and he had the stats and experiences to give himself a good shot, but as we all know, Mayo is a reach for everyone. Early in the cycle, my friend was heartbroken to find out that he was rejected by Mayo. When he told me about it, he seemed pretty disappointed, especially because it was an early rejection. But sometime after, to his surprise, he received an email letting him know that his rejection was being reversed and he is actually being invited to interview now. He was elated of course, but unfortunately for him, he was then either rejected post-interview or waitlisted and then rejected at the end of the cycle. What a roller coaster of emotions.
I actually feel quite bad for my friend. He ended up interviewing at half of the top 20's but was subsequently waitlisted or rejected by all of them only to end up at his "back up option."