anyone know why pfizer vaccine has to get to room temp before mixing, but can then just be refrigerated again?

[pharminfl]

I have to let pfizer vaccine sit for 15 min before mixing diluent. I cant find any reasoning for this. anyone got any theories?

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[Sine Cura]

There's a longer shelf life if frozen.

Have to thaw as it's a frozen suspension, not just a "disc" of virion particles like other vaccines that can or must be frozen

 

[pharminfl]

There's a longer shelf life if frozen.

Have to thaw as it's a frozen suspension, not just a "disc" of virion particles like other vaccines that can or must be frozen

its not the thawing from frozen that i'm wondering about. After I thaw it over several hours in the fridge, why do I need to wait for it reach room temp before mixing the two liquids? after I mix them, the mixture goes right back in the fridge anyways.

 

[M0df]

I haven't seen anything official about this. I think it is mostly because Pfizer says so.

I guess it does make sense for saline and concentrate to be in the same temperature range for better mixing but is it critical? Let's hope not because I don't know if everyone waited 10-15 minutes on their final vial of the day and patients are in a hurry to go get their dinner.