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It was my second letter from an academic "science" source, which is an explicit requirement for many schools, and by the time I started to get real antsy about it, I felt it would have been too late to seek out alternative letter writers (even if they'd agreed, their letters would have been just as late in coming). Furthermore, this particular professor also happened to be my undergraduate advisor, and I felt strongly that he could provide a very intimate, favorable, and accurate assessment of me. I was somewhat limited in my options, too, because I graduated a couple years ago and only really took the bare minimum in hard science courses.
No, no. I mean before submitting AMCAS.