ATP Discrepancy Between Kaplan and TPR

[Sid Steezy]

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Found a weird discrepancy between the Kaplan and TPR when it comes to oxidative phosphorylation. Kaplan says 3 ATP and 2 ATP are produced for NADH and FADH2 respectively while TPR says 2.5 ATP and 1.5 ATP are produced, again, respectively. Which one do I keep in mind for the MCAT?

 

[sillyjoe]

Found a weird discrepancy between the Kaplan and TPR when it comes to oxidative phosphorylation. Kaplan says 3 ATP and 2 ATP are produced for NADH and FADH2 respectively while TPR says 2.5 ATP and 1.5 ATP are produced, again, respectively. Which one do I keep in mind for the MCAT?

There has been some controversy amongst the literature on exactly how much ATP is synthesized per turn of ATP synthase. Therefore, there is controversy surrounding how many ATPs are produced per electron/electron carrier (NADH/FADH2).

That being said, there is a more general consensus now as to how many ATPs are produced per turn of ATP synthase that you will learn in biochemistry at med school 😉. However, for the MCAT you definitely do not need to know this.

In addition, there are different mechanisms by which NADH from glycolysis is shuttled into the mitochondria and depending on which shuttle it uses, a different amount of ATP can be produced per NADH molecule.

Taking this all into consideration, you will not be asked about a the number of ATP produced per NADH/FADH2 unless given a specific value in the passage.

 

[pepocho]

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