B-hydroxybuterate to acetoacetate ratio

[batch5000]

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How does this ratio change in starvation or other disease states? Sorry if the question is vague. I remember this being important somehow. Now I can't find much on it.

 

[Phloston]

Well the only thing you're doing when going from acetoacetate to beta-hydroxybutyrate is going from a ketone to a secondary alcohol, so NADH + H+ ---> NAD+ is used.

Therefore, anything with a high NADH/NAD+, such as ethanol intoxication.

 

[batch5000]

Well the only thing you're doing when going from acetoacetate to beta-hydroxybutyrate is going from a ketone to a secondary alcohol, so NADH + H+ ---> NAD+ is used.

Therefore, anything with a high NADH/NAD+, such as ethanol intoxication.

So in etoh intoxication there would be a higher level of acetoacetate compared to b-hydroxybutyrate?

 

[loveoforganic]

Vice versa I would think. NADH levels would be high, driving it toward b-hydroxybutyrate

 

[Phloston]

So in etoh intoxication there would be a higher level of acetoacetate compared to b-hydroxybutyrate?

NADH is like using NaBH4 or LAH for a reduction, so you'd always be losing a C-O bond.

 

[ijn]

The beta-hydroxybutryate/acetoacetate ratio increases with ketosis, be it alcoholic or diabetic. I remember it was a Kaplan question, but I haven't seen it asked elsewhere.

 

[MrBigglesworth]

5:1 ratio.... I've seen this somewhere too

 

[lemonade90]

I was confused about this also when I read it in FA but had found this to be helpful:

http://www.usmle-forums.com/usmle-step-1-forum/9066-b-hydroxybutyrate-favored-high-redox-states.html

What I got from the above link: basically, B-hydroxy is favored in alcoholism because of high levels of NADH. Acetoacetate is favored in DKA because of low levels of NADH. Recovery from DKA favors B-hydroxy. This makes sense I guess because you are overloaded with NADH in alcoholics.

 

[Azipropofol]

The beta-hydroxybutryate/acetoacetate ratio increases with ketosis, be it alcoholic or diabetic. I remember it was a Kaplan question, but I haven't seen it asked elsewhere.

whenever I read your posts, all I hear is Dr. Raymond's voice lol

 

[lemonade90]

whenever I read your posts, all I hear is Dr. Raymond's voice lol

As Dr. Raymon would say: Slap yourself....but not too hard.

 

[shigella123]

As Dr. Raymon would say: Slap yourself....but not too hard.

LOL...