NEJM - Diagnostic Use of Base Excess (
NEJM - Error)
This was just published last week in the NEJM. I used it as a pre-shift teaching point because of how confusing this topic is to many of our residents -- our trauma surgeons particularly love to know what the base excess (or in their parlance, base deficit) is as soon as a VBG is run, yet most physicians are totally unable to explain what this number actually means. I found this to be an excellent review, and it summarizes the literature well that supports its role in prognostication / risk stratification (read the section "Base Excess in the Acute Care Setting").
I agree with above posters who expressed skepticism about its utility, but if you want to know why the surgeons care or be able to explain what the base excess is if you're pimped on it during rounds, this is a solid article.