Benign Disease

Started by xrt123
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The German POC study from 2018 states single fraction doses are 0.5 - 1.0 Gy to total doses of 2-8 Gy are being used.

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The European (mostly Germany) literature in which the prescription practices are described is relatively few. Many used kV therapies. Those that described their MV prescription practices almost entirely prescribe to isocenter. I have only found 1 publication prescribing to a 3D volume.

60 cgy is one of the more common single fraction doses evaluated. I don't know what developments led to the choice of 60 cgy -- maybe it was an "educated guess". If dose is prescribed to the isocenter, that correlates with a lower dose covering the entirety of the joint. If I prescribe 50 cgy to a volume (the joint) the isocenter dose is between 60 to 100 cgy.

My insurers will only pay for 5 fractions. Therefore, I have limited my prescription to 5 fractions which delivers a total dose to the isocenter meeting or exceeding 300 cgy as described by DEGRO.

Regarding dose/fraction, several in vitro studies have shown more beneficial effects on immunomodulators with doses between 30 - 70 cgy compared with higher doses. The most effective dose/fraction (and total dose) are unknown, as far as I can tell. But, it appears to me that the lower the dose/fraction the greater the anti-inflammatory effect. What should the total dose be? I don't know, but suspect the lower the better there also. There are many patients who report significant pain relief within 1 or 2 fractions. Makes me wonder if those patients really need to complete the remainder of their treatments.

I started out treating 5 x 60 cgy. For the past couple years I have been treating with 5 x 50 cgy to a volume (i.e., the joint). I have treated hundreds of joints with this regimen since and haven't noticed a detriment to response rate.

Fortunately, or unfortunately depending on how you look at it, my arthritis practice has taken off as patients return to their PCP's/Ortho's and they see the results. I had to limit the number of arthritis patients I see in a week as it was crowding out my ability to take care of oncology patients. I have arthritis consults commonly booked out 3+ months now. But, it doesn't seem to bother them as they have already been told by their orthopod that it will be 5-6 mos before they can have surgery for their joint anyway. I am currently treating the spouse of one of my top referrers.

When I started this years ago I did not believe it would work. I thought the Europeans were quacks! I am amazed by what I have seen and wish I had started doing this sooner as it can have a tremendous positive impact on a patient's life.
Thanks for that.

I was worried about getting too busy and not having room for cancer patients, but right now I would really like to fill some of these slots....
 
Just treated someone a few months ago who was on high doses of gabapentin and needed a cane to get around. Now pain free and walking around unassisted. Couldn't be happier.
Forgot to mention that I treated this guy for prostate cancer a few years prior. So his previous hip dose didn't adversely affect his outcomes with LDRT, thankfully.
 
Forgot to mention that I treated this guy for prostate cancer a few years prior. So his previous hip dose didn't adversely affect his outcomes with LDRT, thankfully.
I actually just got this question earlier today from a prostate patient....
 
For those of you who have treated let's say >50-100 patients...

What would you say the breakdown is of sites? Hip v knee v elbow v shoulder v spine v hand etc?
I just worry once I start rolling with this most of my patients will be hip/spine and that anecdotally has less response and "more risk"
 
For those of you who have treated let's say >50-100 patients...

What would you say the breakdown is of sites? Hip v knee v elbow v shoulder v spine v hand etc?
I just worry once I start rolling with this most of my patients will be hip/spine and that anecdotally has less response and "more risk"
Knees have DOMINATED for me

Although the bias is on my end, because I don't aggressively pitch LDRT to like, spine in the same way I pitch to shoulder/hands/knee/feet
 
What would you say the breakdown is of sites? Hip v knee v elbow v shoulder v spine v hand etc?
I just worry once I start rolling with this most of my patients will be hip/spine and that anecdotally has less response and "more risk"
Hands are the most common indication in our hospital.
 
Hands are the most common indication in our hospital.
What's your preferred setup? Or are you using orthovoltage since you're not in American?

The uh...robust body habitus of my countrymen and narrow megavoltage linac table (and CT scan bore) can mean creative hand setups for me.

If only ASTRO hasn't facilitated bundling the OTV code with the orthovoltage code to fight DermRads and effectively kill the orthovoltage market in the USA...
 
What's your preferred setup? Or are you using orthovoltage since you're not in American?

The uh...robust body habitus of my countrymen and narrow megavoltage linac table (and CT scan bore) can mean creative hand setups for me.

If only ASTRO hasn't facilitated bundling the OTV code with the orthovoltage code to fight DermRads and effectively kill the orthovoltage market in the USA...
Every patient gets a direct electron field, 20Mev

And Port Huron ain’t skinny town
 
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What's your preferred setup? Or are you using orthovoltage since you're not in American?

The uh...robust body habitus of my countrymen and narrow megavoltage linac table (and CT scan bore) can mean creative hand setups for me.

If only ASTRO hasn't facilitated bundling the OTV code with the orthovoltage code to fight DermRads and effectively kill the orthovoltage market in the USA...
Orthovoltage works well.

Otherwise, single 6 MV photon field with a 5mm bolus.
 
For those of you who have treated let's say >50-100 patients...

What would you say the breakdown is of sites? Hip v knee v elbow v shoulder v spine v hand etc?
I just worry once I start rolling with this most of my patients will be hip/spine and that anecdotally has less response and "more risk"
Knees and hands. Then feet, hips. Then shoulders.
 
Knees have DOMINATED for me

Although the bias is on my end, because I don't aggressively pitch LDRT to like, spine in the same way I pitch to shoulder/hands/knee/feet
I am unaware of any publications regarding spines. I have done a few and have seen a small response in some. Is there any data out there on spines?
 
I am unaware of any publications regarding spines. I have done a few and have seen a small response in some. Is there any data out there on spines?
I don't think so - I've done a few based on anecdote from others who have seen results.

Mechanistically it makes sense, but because of the lack of reports, I don't actively pitch it (they come to me based on word of mouth, I tell them basically that - "the spine doesn't have the same level of data" - but even with the disclaimer, people are just eager to try anything that isn't surgery)
 
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I've done both prone with hands above head and supine with hands at sides
I was thinking supine with hands above head for the sake of a single field. She's an old rectal patient who had an apr so no prone stuff. Supine at the side is fine but would have to do 2 fields. I'm not crazy about clinical setups in general, though seated would be cool. She's probably not a great stander. You all just treating whole hand? I've been relying on field design from the red journal article with slight mods when appropriate.
 
How is insurance coverage with this. Any Evicore pushback. Doing any IGRT? Or just sim on table?

Who is referring or are you just pushing it to patients already on treatment?
My goodness, need an FAQ or sticky about this somewhere. There's 11 pages of discussion on this. These exact questions have likely been asked and answered in this thread previously.

Insurance is fine. It is in most insurance company's guidelines. No IGRT. Clinical set-up vs CT sim depends on location. Bill complex, not 3D.

Some places (mostly non-academic places) have robust referral patterns already set-up. Some busier places just are offering to their F/Us.
 
My goodness, need an FAQ or sticky about this somewhere. There's 11 pages of discussion on this. These exact questions have likely been asked and answered in this thread previously.

Insurance is fine. It is in most insurance company's guidelines. No IGRT. Clinical set-up vs CT sim depends on location. Bill complex, not 3D.

Some places (mostly non-academic places) have robust referral patterns already set-up. Some busier places just are offering to their F/Us.

My experience is the same.

I have not advertised to anyone outside my own follow-up patients, as I am as busy as I can be at the moment.
 
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My goodness, need an FAQ or sticky about this somewhere. There's 11 pages of discussion on this. These exact questions have likely been asked and answered in this thread previously.

Insurance is fine. It is in most insurance company's guidelines. No IGRT. Clinical set-up vs CT sim depends on location. Bill complex, not 3D.

Some places (mostly non-academic places) have robust referral patterns already set-up. Some busier places just are offering to their F/Us.

Rough estimate of reimbursement if billing as you described? I know it’s payor dependent
 
DAMN. I hear you though. We all keep writing the same things over and over. Same phone calls. Same emails.
 
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Patient I'm about to treat lost em with chemo for rectal cancer a couple years ago. I suspect dose remains too low, but wondered if she might be a special case.
I haven’t faced this issue.

Do you need to treat the DIPs? Or is the pain in the PIPs and MCPs? If no involvement of DIPs, simply spare nails and nail beds out.
 
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