ink PM'd me about this a few days ago! 🙂 Since then, I've thought about it a bit more...
Flying into Kirksville in winter is iffy, IMO. Very often, flights get delayed or turn back to St. Louis due to poor visibility. Kirksville's airport is VERY small. I don't mean small, I mean SMALL. One shack by the runway kinda small. Don't get me wrong, I appreciate having it here, but I have only used it in emergencies.
Plus, you HAVE to fly to STL to get the tiny plane to KV.
STL is about 3.5 easy hours from KV driving; KC is about 3 easy hours from KV.
While xCanadianRagwee's advice about flying into your interview city may be perfectly fine for those going to "real" cities, I would trust the roads more than the KV airport. Especially in Jan/Feb.
Amtrak goes to LaPlata, about 15 min. south of KV. There is no car rental at the station, but your hotel/motel in KV may be able to pick you up if you choose the train. I personally love traveling by train. Unfortunately, you can't fly in to STL and take a direct train to LaPlata. You CAN fly to KC or Chicago and take a train to LaPlata, though.
There, that's my spiel. Good luck on making your arrangements and with your interview! 🙂