bilat renal agenisis vs. infantile cystic ds

[HiddenTruth]

So, in stars, it associated the oligohydramnios, and potters facies, and lung hypoplasia, etc with INFANTILE CYSTIC ds, where as in BRS, they talk about the same pathogenesis, associations and symptoms under BILAT RENAL AGENISIS. Which one is it? I am confused... 😕

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[automaton]

the thing that bilateral renal agenesis and infantile cystic disease have in common is that the kidneys are messed up. in fetuses, amniotic fluid is created by the kidneys. so anything that screws up a fetus' kidney will cause oligohydramnios. potters facies is a consequence of oligohydramnios, as is lung hypoplasia.

so to make a long story short, they're both right.

 

[HiddenTruth]

the thing that bilateral renal agenesis and infantile cystic disease have in common is that the kidneys are messed up. in fetuses, amniotic fluid is created by the kidneys. so anything that screws up a fetus' kidney will cause oligohydramnios. potters facies is a consequence of oligohydramnios, as is lung hypoplasia.

so to make a long story short, they're both right.

ok cool, that makes sense. I thought the oligohydramnios is due to failure of excretion of the amniotic fluid by the "messed up" kidneys after swallowing. Either way, failure of production, excretion, same end result. Thanks.

 

[carrigallen]

interesting note: polyhydramnios (the opposite of oligohydramnios) is caused by esophageal atresia - from the inability to swallow fluid. As mentioned above, oligohydramnois is caused by the inability to properly excrete fluid, from kidney hypofunction.

 

[postcentral]

ok cool, that makes sense. I thought the oligohydramnios is due to failure of excretion of the amniotic fluid by the "messed up" kidneys after swallowing. Either way, failure of production, excretion, same end result. Thanks.

you're also right dude...while most amniotic fluid is derived from maternal tissue by diffusion of the fluid across the amniochorionic membrane from the decidua parietalis, fetal urine (and meconium) help maintain the normal volume of amniotic fluid as pregnancy progresses. so renal agenesis or cystic dz will reduce amniotic fluid levels, leading to oligohydramnios and other associated sequelae. incidently, because fetal urine enters the amniotic fluid, we can do amniocentesis to evaluate fetal metabolism, while epithelial cells which desquamate off the fetus allow us to dx sex and chromosomal abnormalities.

peace

 

[Ramoray]

why does oligo cause lung hypoplasia? is it due to lack of fluid boyuncy support and a pressure on the fetus causing lungs unable to expand in size( not with air) but just in size in utero? anyone

 

[smgilles]

why does oligo cause lung hypoplasia? is it due to lack of fluid boyuncy support and a pressure on the fetus causing lungs unable to expand in size( not with air) but just in size in utero? anyone

low amniotic fluid allows the uterine wall to compress the fetal thorax.

 

[Ramoray]

low amniotic fluid allows the uterine wall to compress the fetal thorax.

Isnt that what i said? thanks though