Biochemistry question

[bassfishindoc]

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Today in biochem our professor was talking about proteins and told us there was only one protein that did not fold at all but instead remained in it's primary structure. He just failed to mention what that protein was and what it's function is. Do any of you guys know what that protein might be?

 

[greatnt249]

Today in biochem our professor was talking about proteins and told us there was only one protein that did not fold at all but instead remained in it's primary structure. He just failed to mention what that protein was and what it's function is. Do any of you guys know what that protein might be?

Sorry, never heard of anything like that. Could it be a peptide hormone, by any chance?

 

[dude1344]

I'd suggest shooting the prof an email to figure out what exactly he meant.

 

[hoqhuuep]

A non-folding protein? Are you sure he didn't mean misfolding protein?

Assuming the former, it'd have to be pretty short in terms of amino acid length, so I'd also guess peptide hormone...

 

[aloepathic]

Actually there are a few proteins (called unfolded proteins) that function in an unfolded state. They are definitely the exception to the rule but they do exist. NACP and 4EBP are two I found in the syllabus an old Biochem class I took.

Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT, Jr, “NACP, a
protein implicated in Alzheimer's disease and learning, is natively unfolded”
Biochemistry 35, 13709-13715 (1997)

Fletcher CM, McGuire AM, Gingras AC, Li H, Matsuo H, Sonenberg N,
Wagner G, “4E binding proteins inhibit the translation factor eIF4E without
folded structure” Biochemistry 37, 9-15 (1998)

 

[Random Anesthesiologist]

these can be simple globular protein which is blood.. it is simple and donot fold it self... some ribosomal protein are also very simple in nature..... try to figure it tout...

"blood" is too general.

There are so many proteinaceous components to "blood" - you'll have to be more specific.