biphosphonate-associated osteonecrosis

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sdn1977

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This time....I'm asking all you students if you have any up-to-date information on this issue. Here is how the question came up....my husband (a dentist) had a pt he referred to an oral surgeon for a possible single implant (to replace a lost tooth rather than make a bridge). The OS declined because of the recent article in the Dec issue of the American Dental Association Journal. So...I read the article...it appears this is more of an issue for pts using biphosphonates for malignancy rather than for osteoporosis (which is why this pt was using Fosamax). IMO, in the population quoted in this article...there might be lots of reasons for this rather than just the biphosphonate, but... Husband feels there were other dental issues as to why OS didn't want to do this and this was yet one more and last reason, but wants to know from me if this is a problem. I really don't know...so I'm asking if you folks have seen recent research. Now...I have lots of pts on biphosphonates...some who have had a variety of procedures involving bone (fractures, knee replacements, etc in addition to dental implants) and none have had this, altho it is a rare & really awful complication, but I'd think it would have occurred in orthopedic procedures as well. I've not read anything indicating this is an issue - have any of you heard of an increased incidence in osteonecrosis (not just dental) in patients receiving biphosphonates for osteporosis? (by the way....you can see the article online - just look up American Dental Association - its in the Dec journal). Thanks for any references!
 
I have actually looked this up at one point...
The studies that I found were rather flawed with an extremely limited population.

you're right about the malignancy thing...
if i remember correctly it was an extremly high dose and even then wasn't all that common.

If i get a chance I'll find the articles

but if any of you other students would like the experience (goodness knows I've had my share it after a month in the DIC).....
do a pubmed search...
dont forget your MeSH terms
 
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