As usual it all depends on the rest of your application. As others have said, 221 isn't really "borderline", and I can't imagine you not making cutoff, except maybe at 1 or 2 programs....if that. And they might not even look at Step 2 for their cutoff anyway. Your score will open a lot of doors, but the rest of the application counts too. And I'll feel better about shouting that from the rooftops after March 15. 😀