It depends what type of place you're looking to match at. As excalibur points out, you should have no problem matching into a good program with that score. If you're shooting for a "top program" though, I would say 221 probably is borderline. If you think 221 was low for you and you can do better, I'd say take it again.
As usual it all depends on the rest of your application. As others have said, 221 isn't really "borderline", and I can't imagine you not making cutoff, except maybe at 1 or 2 programs....if that. And they might not even look at Step 2 for their cutoff anyway. Your score will open a lot of doors, but the rest of the application counts too. And I'll feel better about shouting that from the rooftops after March 15.
isn't every day so painful - waiting, waiting, knowing we can't do anything about it? sorry, i just had to acknowledge someone who's probably feeling the same way i am.
to the OP: if you are a DO, take step II early enough so you can send the results in september when your apps go out. i got a 220 on step I, and a 234 on step II, and several interviewers commented on my step II score being good and helping my application despite my average-ish step I. if you're allo, listen to what everyone else is saying. probably no need; might help you at some of the top programs. just don't do worse.