This is due to reperfusion injury that can happen in MI. Massive Calcium influx you see when the injury is irreversible, lots of Ca2+ in the cytosol causes abnormal contraction of the myocytes , which leads to contraction bands formation.
Irreversible injury: damage to cell membrane and failure of Ca2+-ATPase pump to work, so it wont be able to pump Ca2+ out of the cytosol and you see massive Ca2+ release, which will get into the mitochondria->release of cytochrome c from the mitochondria->caspases get activated->apoptosis.
no apoptosis in MI's the mechanism of death is coagulative necrosis, not apoptosis. Contraction bands bc the hallmark of irreversible cell death is membrane damage, so calcium comes in and promotes contraction like the above post said.
no apoptosis in MI's the mechanism of death is coagulative necrosis, not apoptosis. Contraction bands bc the hallmark of irreversible cell death is membrane damage, so calcium comes in and promotes contraction like the above post said.
