Canine IA RTX for OA knee

[lobelsteve]

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Long-term pain relief in canine osteoarthritis by a single intra-articular injection of resiniferatoxin, a potent TRPV1 agonist. - PubMed - NCBI


How soon til we start seeing this in people?

 

[deleted185747]

Sounds amazing

 

[Ducttape]

A long time.

Single injection in 1 dog. Lots more research needs to be done.

 

[SommeRiver]

I met a guy at NANS who does intra-articular pulsed ablation for knee OA. Cash procedure. I have no clue how or why that would work.

So this is basically Prialt into a dog's knee?

 

[lobelsteve]

A long time.

Single injection in 1 dog. Lots more research needs to be done.

7 dogs, different breeds and weights posted. Or I linked wrong article.
Proof of concept?

 

[painfree23]

I met a guy at NANS who does intra-articular pulsed ablation for knee OA. Cash procedure. I have no clue how or why that would work.

So this is basically Prialt into a dog's knee?

What is he ablating?

 

[SommeRiver]

What is he ablating?

Pain...

 

[pastafan]

I met a guy at NANS who does intra-articular pulsed ablation for knee OA. Cash procedure. I have no clue how or why that would work.

So this is basically Prialt into a dog's knee?

Because he is also injecting steroid in the joint?

 

[SommeRiver]

Because he is also injecting steroid in the joint?

No, this was separate. It was a stand alone pulsed RF that he charged like 400 bucks to do it. He said it worked occasionally but I don't see why someone would ever even think about offering that to a pt. What mechanism are you manipulating? What anatomy is being targeted?

I would rather have someone give me an intra-articular vape off a CBD pen.

 

[hyperalgesia]

What is he ablating?

Cash

 

[Ducttape]

No, this was separate. It was a stand alone pulsed RF that he charged like 400 bucks to do it. He said it worked occasionally but I don't see why someone would ever even think about offering that to a pt. What mechanism are you manipulating? What anatomy is being targeted?

I would rather have someone give me an intra-articular vape off a CBD pen.

Read that placebo article that lobel posted.

Maybe the injection activated the COMT pathway...

 

[Orin]

So this is basically Prialt into a dog's knee?

No this is supposed to destroy the TRPV1 fibers. It's basically superpotent capsaicin.

I suspect we'll be doing this in people in trials over the next 6 - 12 months if not sooner, as they are already doing trials in people intrathecally/epidurally.