Carbonyl + primary Amine or NH3 = Amide or Imine??

[clubwestpua]

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I see when amine or NH3 is added to Aldehyde, the resulting product is imine.

However, I see Carbonyl Halide (Acyl Halide) + amine or NH3, then the product is amide.

How do I distinguish these two?

Ketone or Aldehyde + Amine = Imine or enamine?
Acyl Halide, Anhydride, Acid, Ester + Amine = Amide??

 

[DDS Perez]

Aldehydes and ketones react to for Imides or Enamides


On the oher hand... Acyl Chlorides, Esters and any carboxylic acid derivative will for Amide. THe reason is that all the carboxylic derivatives have good leaving groups attached to the carbonyl group therefore great for nucleophilic substitition reactions.

Ketones and aldehydes dont have good leaving groups attacked to the carbonyl (methyl or hydrogen!!! not good leaving groups at all) therefore they under nucleophilic ADDITION reactions.


Tell destroyer to give you that explanation ! 👍 good luck!

 

[clubwestpua]

Aldehydes and ketones react to for Imides or Enamides


On the oher hand... Acyl Chlorides, Esters and any carboxylic acid derivative will for Amide. THe reason is that all the carboxylic derivatives have good leaving groups attached to the carbonyl group therefore great for nucleophilic substitition reactions.

Ketones and aldehydes dont have good leaving groups attacked to the carbonyl (methyl or hydrogen!!! not good leaving groups at all) therefore they under nucleophilic ADDITION reactions.


Tell destroyer to give you that explanation ! 👍 good luck!

Thanks! Dr. Romano should definitely include your exp in 2013 destroyer!! 👍👍