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For the residents, how many of you have personal experience with diagnosed psychogenic non-epileptic seizures? Or really psychogenic disorders of any kind that you or an attending diagnosed and then pursued to treat. I guess I'm asking "What would YOU do?" with the following, highly-disguised, patient.
Right now, we have a 52-yo AAF with a h/o extensive cosmetic surgeries and depression who was hospitalized on neuro/med for seizure activity. 6 months ago she began experiencing automatisms, like blinking rapidly and making clicking noises in her throat several times a day. 2 months ago she noticed clonic spasms of the UE, then LE, and received the bells-and-whistles Neuro workup at a nearby, well-respected regional center. No findings. 24-hr-EEG with no seizure activity. MRI of everything normal. Started on Keppra 500 TID. Sleep studies normal. Yesteday she was unpacking one of her college-age children's bags at home when she noticed she was perseverating with meaningless actions (repeatedly closing doors, etc). Then she entered an hour long tonic-clonic state with barking vocalizations. Her children called the bus and it took a horseload of Ativan (10 mg) and Dilantin loading to "break" her status.
Key fact: She retains perfect consciousness through all of this. There is no classic post-ictal of any kind. She remembers everything that is said.
Psychosocial: Her depression was attributed to her husband's repeated infidelity, after leaving his first wife to be with her. She had been on Prozac 60mg until two years ago, when it was d/c due to "getting well." All of her surgical activity and a grueling workout schedule with supplements too numerous to count initiated at the time of discovery of the infidelity, four years ago. She is persistently evasive when asked directly about her home life or psychiatric history. She denies anxiety but her affect, physical demeanor, and thought content reveal extensive preoccupation with her physical health and how she needs a definitive answer to her seizures but expresses apathy at pursuing any non-neurologic workup. I should mention at this moment that she was in healthcare previously.
Labs: Only significant for a CK of 1400. So she is convulsing, and having witnessed one event I can say with certainty that her extremities undergo asymmetric spasms (R more than L). But she responds to vocal commands (such as "open your eyes") while the contractions continue.
Meds prior: Keppra as I mentioned, Diazepam 2mg for flying, and an exhaustive list of vitamins.
Differential: Frontal lobe seizures, possible hyperkinetic, vs. PNES, either from conversion or factitious. My money is on the psychiatric diagnosis, even though it is a dx of exclusion.
Where do we go with her that would be helpful, ethical and appropriate?
Right now, we have a 52-yo AAF with a h/o extensive cosmetic surgeries and depression who was hospitalized on neuro/med for seizure activity. 6 months ago she began experiencing automatisms, like blinking rapidly and making clicking noises in her throat several times a day. 2 months ago she noticed clonic spasms of the UE, then LE, and received the bells-and-whistles Neuro workup at a nearby, well-respected regional center. No findings. 24-hr-EEG with no seizure activity. MRI of everything normal. Started on Keppra 500 TID. Sleep studies normal. Yesteday she was unpacking one of her college-age children's bags at home when she noticed she was perseverating with meaningless actions (repeatedly closing doors, etc). Then she entered an hour long tonic-clonic state with barking vocalizations. Her children called the bus and it took a horseload of Ativan (10 mg) and Dilantin loading to "break" her status.
Key fact: She retains perfect consciousness through all of this. There is no classic post-ictal of any kind. She remembers everything that is said.
Psychosocial: Her depression was attributed to her husband's repeated infidelity, after leaving his first wife to be with her. She had been on Prozac 60mg until two years ago, when it was d/c due to "getting well." All of her surgical activity and a grueling workout schedule with supplements too numerous to count initiated at the time of discovery of the infidelity, four years ago. She is persistently evasive when asked directly about her home life or psychiatric history. She denies anxiety but her affect, physical demeanor, and thought content reveal extensive preoccupation with her physical health and how she needs a definitive answer to her seizures but expresses apathy at pursuing any non-neurologic workup. I should mention at this moment that she was in healthcare previously.
Labs: Only significant for a CK of 1400. So she is convulsing, and having witnessed one event I can say with certainty that her extremities undergo asymmetric spasms (R more than L). But she responds to vocal commands (such as "open your eyes") while the contractions continue.
Meds prior: Keppra as I mentioned, Diazepam 2mg for flying, and an exhaustive list of vitamins.
Differential: Frontal lobe seizures, possible hyperkinetic, vs. PNES, either from conversion or factitious. My money is on the psychiatric diagnosis, even though it is a dx of exclusion.
Where do we go with her that would be helpful, ethical and appropriate?
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